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KMID : 0361020000430091001
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 9 p.1001 ~ p.1004
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The Rosai-Dorfman Disease of th Nasal Cavity and Salivary Gland : A Case Report
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Cho Chang-Hyun
Lee Won-Sang
Choi Jae-Young
Park Chan-Il
Park Jun-Ho
Kang Hae-Youn
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Abstract
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Rosai-Dorfman Disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a rare idiopathic histiocytosis that most commonly involves the cervical lymph nodes. Extranodal involvement occurs in 30-40% of cases, most often in the head and neck. Characteristic histological findings include emperiopolesis (intracellular engulfment) of lymphocytes and S-100 protein positivity. Treatment of Rosai-Dorfman disease is unnecessary unless the disorder becomes life-threatening, since the disease will resolve spontaneously in most patients. We experienced a case of extranodal RDD at the nasal cavity as the initial lesion prior its nodal involvement. The patient was a 18-year-old woman who complained of nasal obstruction for 4 years and had a submandibular mass that persisted during the last 3 months. Histologically, all specimens taken from the left nasal cavity, the left submandibular mass and the left upper jugular lymph node showed heavy infiltration of plasma cells, lymphocytes and sheets of macrophages with abundant pale cytoplasm which replaced the existing organ architecture.
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KEYWORD
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Rosai-Dorfman disease, Nasal cavity, Salivary gland
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